Zakir Khan was born on August 20, 1987, in Indore, Madhya Pradesh, India. He is currently single and has not publicly disclosed any information about a spouse or romantic relationship. Zakir comes from a family with a rich musical heritage, being the grandson of Ustad Moinuddin Khan, a renowned Sarangi player. He initially pursued music and dropped out of college to focus on his passion for comedy, which eventually led him to become one of India's most popular stand-up comedians.

Zakir Khan's career took off in 2012 when he won Comedy Central's competition "India's Best Stand Up." His unique comedic style, characterized by relatable humor and the catchphrase "Sakht Launda," resonated with audiences across India. He has since released several successful stand-up specials on Amazon Prime Video, including "Haq Se Single" and "Mannpasand." In addition to stand-up, Zakir has appeared in various television shows, served as a mentor on "The Great Indian Laughter Challenge," and co-hosted "On Air with AIB." His engaging performances and ability to connect with fans have made him a prominent figure in the Indian comedy scene.