Palash Sen was born on September 23, 1965, in Lucknow, India. He grew up in Delhi's Connaught Place and comes from a family of doctors, being the 17th generation in his lineage. Palash studied medicine at the University College of Medical Sciences and Guru Teg Bahadur Hospital in New Delhi, earning an M.B.B.S. degree. He is married to Shalini Sen, a scientist. Palash is best known as the founder and frontman of Euphoria, India's first Hindi rock band, which he established during his college years.